{"id":3004,"date":"2008-09-20T19:02:42","date_gmt":"2008-09-21T02:02:42","guid":{"rendered":"http:\/\/www.meehawl.com\/Blogfiles\/?p=3004"},"modified":"2008-09-20T19:02:42","modified_gmt":"2008-09-21T02:02:42","slug":"infant-paracetemol-use-linked-with-later-asthma-eczema","status":"publish","type":"post","link":"https:\/\/www.meehawl.com\/Blogfiles\/2008\/09\/20\/19\/02\/infant-paracetemol-use-linked-with-later-asthma-eczema\/","title":{"rendered":"Infant Paracetemol Use Linked With Later Asthma, Eczema"},"content":{"rendered":"<blockquote><p><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140673608614452\/abstract\">Use of paracetamol for fever in the first year of life was associated with an increased risk of asthma symptoms when aged 6\u00e2\u20ac\u201c7 years (OR 1\u00c2\u00b746 [95% CI 1\u00c2\u00b736\u00e2\u20ac\u201c1\u00c2\u00b756]). Current use of paracetamol was associated with a dose-dependent increased risk of asthma symptoms (1\u00c2\u00b761 [1\u00c2\u00b746\u00e2\u20ac\u201c1\u00c2\u00b777] and 3\u00c2\u00b723 [2\u00c2\u00b791\u00e2\u20ac\u201c3\u00c2\u00b760] for medium and high use vs no use, respectively). Use of paracetamol was similarly associated with the risk of severe asthma symptoms, with population-attributable risks between 22% and 38%. Paracetamol use, both in the first year of life and in children aged 6\u00e2\u20ac\u201c7 years, was also associated with an increased risk of symptoms of rhinoconjunctivitis and eczema.<\/a><\/p><\/blockquote>\n<p>It&#8217;s been known for a long time that the <a href=\"http:\/\/www.google.com\/search?num=100&amp;hl=en&amp;safe=off&amp;sa=X&amp;oi=spell&amp;resnum=0&amp;ct=result&amp;cd=1&amp;q=aspirin+asthma+leukotriene&amp;spell=1\" target=\"_blank\">interaction of NSAID COX inhibitors such as aspirin or paracetemol\/acetominophen with the leukotriene pathway in humans can initiate asthma<\/a> by shunting more of the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Lipoxygenase\" target=\"_blank\">5-Lipo output<\/a> <a href=\"http:\/\/en.wikipedia.org\/wiki\/Leukotriene\" target=\"_blank\">down the LT pathway<\/a> resulting in rapid <a href=\"http:\/\/en.wikipedia.org\/wiki\/Leukotriene#Leukotrienes_in_asthma\" target=\"_blank\">adverse bronchial symptoms<\/a>. However, this is the first time I&#8217;ve seen such strong evidence that skewing the pathway so early in post-natal development can produce measurable immunological effects several years down the development path.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Use of paracetamol for fever in the first year of life was associated with an increased risk of asthma symptoms when aged 6\u00e2\u20ac\u201c7 years (OR 1\u00c2\u00b746 [95% CI 1\u00c2\u00b736\u00e2\u20ac\u201c1\u00c2\u00b756]). Current use of paracetamol was&#46;&#46;&#46;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[920,916,635,918,921,922,928,930,917,926,919,10,924,915,927,929,923],"tags":[1721,1717,1477,1719,1722,1723,1728,1730,1718,1726,1720,1368,925,1725,1716,1727,1729,1724],"class_list":["post-3004","post","type-post","status-publish","format-standard","hentry","category-5-lipoxygenase","category-acetominophen","category-aspirin","category-asthma","category-cox","category-cyclooxygenase","category-eczema","category-epidemiology","category-health","category-immunology","category-leukotriene","category-medicine","category-nsaids","category-paracetemol","category-rheumatology","category-rhinoconjunctivitis","category-the-lancet","tag-5-lipoxygenase","tag-acetominophen","tag-aspirin","tag-asthma","tag-cox","tag-cyclooxygenase","tag-eczema","tag-epidemiology","tag-health","tag-immunology","tag-leukotriene","tag-medicine","tag-non-steroidal-anti-inflammatory-drugs","tag-nsaids","tag-paracetemol","tag-rheumatology","tag-rhinoconjunctivitis","tag-the-lancet"],"aioseo_notices":[],"jetpack_featured_media_url":"","jetpack-related-posts":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/posts\/3004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/comments?post=3004"}],"version-history":[{"count":0,"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/posts\/3004\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/media?parent=3004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/categories?post=3004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.meehawl.com\/Blogfiles\/wp-json\/wp\/v2\/tags?post=3004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}