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Blood Voices

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Analysis of [cerebrospinal fluid] samples showed a differential distribution of metabolites in samples from healthy volunteers away from drug-naïve patients with first-onset schizophrenia … The metabolic profile … was characteristically altered in patients with schizophrenia … Whilst the drug-naïve patients with first-onset schizophrenia clustered very tightly together, a small number of samples did not show a clear separation … this may indicate the existence of schizophrenia subgroups … the increased concentrations of glucose together with other metabolic perturbations, such as lower levels of acetate and lactate, and a pH-dependent shift in glutamine resonances, may represent a more specific disease diagnostic for schizophrenia.

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